Author(s): Petra Honainy
Mentor(s): Jane Flinn, Psychology
symptoms in neurodegenerative diseases such as Alzheimer‘s disease and Traumatic Brain
Injury (TBI). Prior research shows that cognitive deficits improve with young blood plasma, but
there is little research on how young blood plasma mitigates motor deficits. Our study inspects
whether young blood plasma can improve motor deficits in mice with TBI. The mice in the study
are either induced with a TBI and an injection of saline or young blood plasma, or the mice are
not induced with a TBI and injected with saline or young blood plasma. The mice then do the
wire hanging and Rotarod test where their motor functioning is assessed.
Groups that are impacted from TBI include people who play high impact sports, one of the most infamous cases resulting from football, but this is certainly not the only sport. Young children and elderly populations are largely at risk because they both are at high risk for falls and other physical accidents.
You could see how these groups who already have diminished motor skills could really be in trouble if they obtain a TBI that will worsen these motor skills.
Right now, long, and frustrating work with physical and occupational therapists are the best that we have that can help with TBI symptoms. So, I suggest an alternative solution involving blood transfusions that could lead to better outcomes and less time in a clinic.
Young blood plasma has been shown to cause benefits in older mice such as synaptic plasticity, higher dendritic spine number, which is like increasing the strength of the neurons, and inducing adult neurogenesis, which is forming more neurons from premature ones. If this happens in areas of the brain controlling motor activity, this could be very beneficial in improving motor symptoms. It has been previously found that mouse brain function improves with young blood administration, but this research is limited, and more tests need to be done which is what I propose.
We will work on this in the lab. First, mice will be given a TBI using an apparatus like the one shown for about a week. Next, these mice are administered blood from young mice for 15 days. After this, tests will be conducted to look at motor skill, using the rotarod and wire hanging test. Both use the fact that longer times indicate better motor control. Finally, we will look at the data and see if motor skills have improved.
If motor skills do improve, we are one step closer in seeing the value of young blood that could one day apply to humans. This type of research provides a new route in treatments for debilitating irreversible diseases like TBI.
Research on the mechanisms of how young blood plasma can help with deficits needs to occur once we have comprehensive data showing the benefits of using young blood.